The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF- B pathway
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چکیده
منابع مشابه
Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis
Objective(s): Myocarditis is characterized by inflammatory cell infiltration in myocardial stroma. Attenuation of tumor necrosis factor (TNF)-α and interleukin (IL)-1β is a reliable mark for improving the prognosis. Protein kinase B (Akt) plays an important role in the development and progression of myocarditis. The specific role of the natural inhibitor of Akt, Deguel...
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Tobacco carcinogens induce Akt activation and lung carcinogenesis. We previously demonstrated that deguelin, a natural plant product, specifically inhibits the proliferation of premalignant and malignant human bronchial epithelial cells by blocking Akt activation. To evaluate the ability of deguelin to block tobacco carcinogen-induced lung tumorigenesis, we evaluated the in vivo effects of degu...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2006
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgl162